DTaP-IPV-Hib Vaccine(diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine, Pentacel version 1 Package Insert (Feb. 2021), Pentacel version 2 Package Insert (Dec. 2019), version 1: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, aluminum phosphate, MRC-5 cells,, CMRL (Connaught Medical Research Laboratories) 1969 medium (supplemented with calf serum), Medium 199 (without calf serum), 2-phenoxyethanol, water, semi-synthetic medium, version 2: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-beta310 cyclodextrin, glutaraldehyde, Vero cells, Iscoves medium (supplemented with calf serum), M199 medium without calf serum, 2-phenoxyethanol, water, version 1: filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, polysorbate 80, sucrose, formaldehyde, glutaraldehyde, bovine serum albumin, 2-phenoxyethanol, neomycin, polymyxin B sulfate. Vaccines, like any medicine, can have side effects. 2021), sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, and polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Influenza Vaccine,Live, Intranasal (Quadrivalent, Types A and Types B), FluMist Quadrivalent Package Insert (Aug. 2021), specific pathogen-free (SPF) eggs, stabilizing buffer, monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, ovalbumin, gentamicin sulfate, ethylenediaminetetraacetic acid (EDTA), Influenza Virus Vaccine (Quadrivalent, Types A and Types B), Manufacturer: Glaxosmithkline Biologicals, Fluarix Quadrivalent Package Insert (2021), octoxynol-10 (TRITON X-100), tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, Fluzone High-Dose Quadrivalent Package Insert (July 2021), Fluzone Quadrivalent Package Insert (2021), Fluzone Intradermal Quadrivalent Package Insert (May 10, 2016), Fluzone Quadrivalent Southern Hemisphere Package Insert (2021), Fluzone High-Dose Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution , octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent Southern Hemisphere: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Quadrivalent: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Intradermal Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Quadrivalent Southern Hemisphere: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Flulaval Quadrivalent Package Insert (2021), phosphate-buffered saline solution, ovalbumin, formaldehyde, sodium deoxycholate, -tocopheryl hydrogen succinate, polysorbate 80, Japanese Encephalitis Virus Vaccine, Inactivated, Adsorbed, Vero cells, protamine sulfate, sucrose density gradient, formaldehyde, aluminum hydroxide, formaldehyde, bovine serum albumin, host cell DNA, sodium metabisulphite, host cell protein, protamine sulfate, 23. Get CDCs official recommended immunization schedules for children, adolescents, and adults. Antigens can be considered the active ingredients in vaccines because they are the parts of the vaccine to which an immune response is generated. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Morrison VA, Oxman MN, Levin MJ, Schmader KE, Betts RF, et al. To receive email updates about this page, enter your email address: We take your privacy seriously. Protection stays above 85% for at least the first four years after you get vaccinated. Common Ingredients: beef extract, acid hydrolysate of casein, starch, agar, Common Ingredients: glucose, sodium chloride, sodium phosphate dibasic, monopotassium, phosphate, magnesium sulfate hydrate, ferrous sulfate heptaphydrate, cystine hydrochloride, tyrosine hydrochloride, urasil hydrochloride, Ca-pantothenate in ethanol, thiamine in ethanol, pyridoxin-hydrochloride in ethanol, riboflavin in ethanol, biotin in ethanol, sodium hydroxide, beef heart infusion (de-fatted beef heart and distilled water), casein solution. Safety, tolerability, and immunogenicity of zoster vaccine in subjects with a history of herpes zoster. Symptoms of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. An older adult with shingles is more likely to develop PHN and have longer lasting and more severe pain than a younger person. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. Afluria Quadrivalent: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Quadrivalent Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Flucelvax Quadrivalent Package Insert (Mar. Hum Vaccin. Rarely, shingles can lead to complications such as pneumonia, hearing problems, blindness, brain inflammation (encephalitis), or death. Common Shingrix side effects include: headache, muscle pain; feeling tired; stomach pain, nausea, vomiting, diarrhea; fever, shivering; or. Remind your patients that the pain from shingles can last a lifetime, and these side effects should only last 2 to 3 days. An allergic reaction could occur after the vaccinated person leaves the clinic. Most side effects are mild to moderate, and last 1-3 days. 2021), Madin Darby Canine Kidney (MDCK) cells, culture medium, -propiolactone, cetyltrimethylammonium bromide, phosphate buffered saline, MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, propiolactone, thimerosal, Influenza Virus Vaccine (Trivalent, Types A and B), Afluria Southern Hemisphere Package Insert (2021), Afluria: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta375 propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, Afluria Southern Hemisphere: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, Afluria: sodium chloride, monobasic sodium, phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, phosphate-buffered saline solution, thimerosal, ovalbumin, formaldehyde, sodium deoxycholate, -tocopheryl hydrogen succinate, polysorbate 80, Influenza Vaccine, Live, Intranasal (Trivalent, Types A and B), [Editors Note: This vaccine was approved on July 9, 2020, and, as of Nov. 1, 2021, the FDA had not uploaded the package insert. Origins of Sexual Orientation, DTap-HepB-IPV (diphtheria, tetanus, pertussis, hepatitis B, & polio), DTap-IPV (diphtheria, tetanus, pertussis, & polio), DTaP-IPV-Hib-HepB (diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), DTaP-IPV-Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), Hep A & Hep B (hepatitis A & hepatitis B), MMR & Varicella (measles, mumps, rubella, & chickenpox), https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad, https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist, https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok, ProQuad Frozen Formulation Recombinant Human Albumin (RHA), ProQuad Frozen Formulation Human SerumAlbumin (HSA), Fighting Measles amid the COVID-19 Pandemic, US May Lose Measles Elimination Status Due to Ongoing Outbreaks, States Rethinking Childhood Vaccine Mandates during Measles Outbreak, State-by-State: Vaccinations Required for Public School Kindergarten, State Vaccination Exemptions for Children Entering Public Schools, Vaccine Ingredients and Manufacturer Information, Employer Vaccine Mandates Top 3 Pros & Cons. Information on how to submit a report to VAERS is available at VAERS website, or by calling 1-800-822-7967. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. "Vaccine Ingredients and Manufacturer Information." Many people have redness and swelling on their arm spanning several inches where they got the shot. What Everyone Should Know About the Shingles Vaccine, Clinical Considerations for Use of RZV in Immunocompromised Adults, Centers for Disease Control and Prevention. Vaccine Information Statement Gagliardi AM, Gomes Silva BN, Torloni MR, Soares BG. What to tell patients about Shingrix benefits: What to tell patients about Shingrix side effects: We take your privacy seriously. loss of bladder or bowel control. filamentous hemagglutinin (FHA), pertactin (69 kiloDalton outer membrane protein), aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80). These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Common Ingredients: tris hydrochloride, tris base, glutamate (monosodium salt), proline, salt, monopotassium phosphate, potassium chloride, magnesium chloride, calcium chloride, ferrous sulfate, ascorbic acid, niacin, glutathione. J Infect Dis. Last modified on November 28, 2022. After you have chickenpox, the virus stays in your body and can cause shingles later in life. Prevention of herpes zoster: Recommendations of the Advisory Committee on Immunization Practices (ACIP). If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad], Afluria Quadrivalent Package Insert (Mar. Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. Shingles (also called herpes zoster) is the disease caused when the chickenpox virus reactivates. procon@eb.com, 2022 Encyclopaedia Britannica, Inc. Vaccine. Alison Weiss, The Genus Bordetella, The Prokaryotes: A Handbook on the Biology of Bacteria, Ed. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. See. MMR Vaccine(measles, mumps, & rubella), Measles, Mumps, and Rubella Virus Vaccine, Live, chick embryo cell culture; WI-38 human diploid lung fibroblasts, recombinant human serum albumin, fetal bovine serum, sorbitol, sucrose, hydrolyzed gelatin, recombinant human albumin, fetal bovine serum, neomycin, other buffer and media ingredients, 24. Among immunocompetent adults 50 years and older, the efficacy of two doses of Shingrix for the prevention of herpes zoster (shingles) was high among all age groups. Also, you are more likely to have severe, long-term pain if you get shingles when you are older. Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia(PHN), the most common complication from shingles. The FDA adds that individuals older than 18 at a higher risk of shingles are also eligible for the vaccine. The Vaccine Adverse Event Reporting System (VAERS) is an early warning system, co-managed by CDC and FDA, that monitors for potential vaccine safety problems. CDC twenty four seven. 5 Additionally, Shingrix is not egg-based, and it does not contain thimerosal , a mercury-containing preservative. These can include cool. Saccharomyces cerevisiae cells, aluminum hydroxide, listyeast protein. Cookies used to make website functionality more relevant to you. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. In eight clinical trials of more than 10,000 immunocompetent participants 50 years or older, grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common after patients received Shingrix. You should plan to avoid strenuous activities, such as yardwork or swimming, for a few days after vaccination. Ask your health care provider for guidance. These cookies may also be used for advertising purposes by these third parties. A New Vaccine to Prevent Herpes Zoster, NEJM. A casein is a family of phosphoproteins commonly found in mammalian milk. In addition to the rash, shingles can cause fever, headache, chills, or upset stomach. Tseng HF, Liu A, Sy L, Marcy SM, Fireman B, et al. Shingles is caused by varicella-zoster virus, the same virus that causes chickenpox. 2012 May;271(5):510-20. You may get the Shingrix vaccine even if you've already had shingles. Antibiotics , like neomycin, to help keep outside germs and bacteria from growing in the vaccine. Any adverse events following vaccination can be reported to the Vaccine Adverse Event Reporting System (VAERS). Vaccination is a safe and effective way to protect you from serious disease caused by shingles. Prevention of herpes zoster: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Accessed February 21, 2023. https://vaccines.procon.org/vaccine-ingredients-and-manufacturer-information/, Born Gay? Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. All information these cookies collect is aggregated and therefore anonymous. 2-Phenoxyethanol is a glycol ether used as a preservative in vaccines. Shingrix is now covered by most health insurance plans. You can review and change the way we collect information below. CDC twenty four seven. pain, redness, or swelling where the shot was given. The fetal fibroblast cells used to grow vaccine viruses were first obtained from elective termination of two pregnancies in the early 1960s. Three vaccines licensed for use by the FDA (plague, poliovax, and rabies vaccine adsorbed) are listed on the FDA site, but do not have available package inserts or other information, and thus are not included below. Some vaccines, like influenza (flu) vaccines, are modified frequently and you may wish to consult your doctors office or pharmacy for the most current information. Zostavax will no longer be sold in the United States starting July 1, 2020. See http://www.immunize.org/visexternal icon. People who are moderately or severely ill should usually wait until they recover before getting recombinant shingles vaccine. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Simberkoff MS, Arbeit RD, Johnson GR, Oxman MN, Boardman KD, et al. Severe allergic reactions to Shingrix are very rare. DTaP-IPV-Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), 16. 8. Aluminum is used in vaccines as an adjuvant, which helps the vaccine work more quickly and more powerfully. Getting vaccinated is the best way to prevent shingles. Many people have redness and swelling on their arm spanning several inches where they got the shot. While Shingrix is not contraindicated in immunocompromised people, the Advisory Committee on Immunization Practices (ACIP) at this time does not recommend it for this population. Side effects are more common in younger people. MMWR. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. People with minor illnesses, such as a cold, may be vaccinated. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. . version 2: filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, polysorbate 80, 2-phenoxyethanol, sucrose, formaldehyde, glutaraldehyde, bovine serum albumin, streptomycin sulphate, neomycin, polymyxin B sulphate. Cookies used to make website functionality more relevant to you. in adults aged 18 years and older who are or will be at increased risk of HZ due to immunodeficiency or immunosuppression caused by known disease or therapy. CDC twenty four seven. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. In addition to the rash, shingles can cause fever, headache, chills, or upset stomach. Both vials of Shingrix must be refrigerated at a temperature of 36-46 F. Do not use if exposed to temperatures below 36 F. Prepare Shingrix by reconstituting the antigen component with the adjuvant suspension component. Safety of herpes zoster vaccine in the shingles prevention study: A randomized trial. The most commonly reported systemic symptoms were fatigue and myalgia. Controversial products used to make vaccines include but are not limited to: African Green Monkey (Vero) cells, aluminum, cow products, Cocker Spaniel cells, formaldehyde, human fetal lung tissue cells, insect products, and mouse brains. Shingles vaccine for older adults Shingles is caused by the same virus as chickenpox. The two doses should be separated by two to six months. You can protect yourself against shingles. You may have heard you can pass the virus to others if you get the Zostavax shingles vaccine. However, there are no data or theoretical concerns to indicate that Shingrix would be less safe or less effective when given at an interval shorter than 5 years following Zostavax. You can submit a report of your side effects to the Vaccine Adverse Event Reporting System through the website (. Thank you for taking the time to confirm your preferences. About 1 out of 6 people had symptoms severe enough to prevent them from doing regular activities. Vaccine. Schmader KE, Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, et al. Basic information about the shingles vaccine, Vaccine recommendations and contraindications; composition, dosage, administration, and co-administration with other vaccines; Shingrix FAQ; storage and handling. Shingrix is also recommended for adults 19 years and older who have weakened immune systems because of disease or therapy. ZOSTAVAX is a vaccine that is used for adults 50 years of age or older to prevent shingles (also known as zoster). 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