Some cases had a fatal outcome. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca COVID-19 vaccine (ChAdOx1-S [recombinant] vaccine). Success! November 2020 - Trial data dispute. 6 Renaissance Way Keep this leaflet. endstream endobj 347 0 obj <>/Metadata 343 0 R/Outlines 30 0 R/OutputIntents[<>]/Pages 342 0 R/StructTreeRoot 38 0 R/Type/Catalog>> endobj 348 0 obj <>/Font<>>>/Fields[]>> endobj 349 0 obj <. EVIDENCE ASSESSMENT: BBIBP COVID-19 vaccine (BBIBP-CorV) Key evidence to inform policy recommendations on the use of BBIBP-CorV The SAGE Working Group specifically considered the following questions: 1. endstream endobj startxref United Kingdom, MedImmune Pharma B.V., Nijmegen 0000100169 00000 n The AstraZeneca vaccine is not a live virus vaccine, it is therefore biologically and clinically unlikely to pose a risk to the breastfeeding child. "It can't give you an infection. This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. Known to be a potential allergen. Talk to the healthcare provider if you have questions. Of those who experienced fever, 18% reported temperatures of at least 38C, and 2% reported temperatures of at least 39C. A booster dose may be considered 4 6 months after completion of the primary vaccination series, starting with the higher priority-use groups, in accordance with the WHO Prioritization Roadmap. Like all medicines, this vaccine can cause side effects, although not everybody gets them. Efficacy. 2021 Jan 9;397(10269):72-74. doi: 10.1016/S0140-6736(20)32623-4. WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. Dont worry we wont send you spam or share your email address with anyone. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. Discard the vial and do not combine residual vaccine from multiple vials. 0000007190 00000 n endstream endobj 76 0 obj <> stream 0000053643 00000 n %%EOF AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. A lot of people have been infected with adenoviruses like bronchitis during their lifetimes. Browse our homepage for up to date content or request information about a specific topic from our team of scientists. Interim results were published in. The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. No data are currently available on the use of COVID-19 Vaccine AstraZeneca in children and adolescents younger than 18 years of age. This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. These include: y If you miss a scheduled injection, you may not be fully protected against COVID-19. 0000098956 00000 n COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients URL is not yet ready. See section 4. /Root 55 0 R 967 0 obj <>stream For the Oxford-AstraZeneca vaccine, 30 cases of anaphylaxis have been confirmed . Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. b t@f&!+:eez8YY8.j 7 If side effects such as pain and/or fever are troublesome, medicines containing paracetamol can be taken. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. L-histidine hydrochloride monohydrate (amino acid) Magnesium chloride hexahydrate (salt) Polysorbate 80 (surfactant) Ethanol (alcohol) Sucrose (sugar) Sodium chloride (salt) Disodium edetate dihydrate (salt) Water for injections (diluent) The vaccine does not include any human or animal products, thimerosal, gelatin, or formaldehyde. Explanation of ingredients: - mRNA: Like the Pfzer BioNTech vaccine, Moderna's also uses mRNA technology to build antibodies against COVID-19. Each vial contains 10 doses of 0.5 ml. Younger patients may be more likely to experience anaphylaxis. Page last updated Thursday, May 26, 2022 0000093244 00000 n 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca]in pregnant women, or women who became pregnant after receiving the vaccine. 0000006590 00000 n Vaccines are widely used to prevent infections, and most traditional vaccines that target viruses are made from dead or attenuated live viruses (viruses that have been altered so they are not harmful) to help people develop immunity without becoming ill. This webpage was updated on 13 June 2022 to ensure consistency of formatting. We also use cookies set by other sites to help us deliver content from their services. Generic name: SARS-CoV-2 vaccine 0000000016 00000 n % AstraZeneca-Oxford vaccine was 76% effective at preventing symptomatic COVID-19 two weeks after the second dose and was 100% effective in stopping severe disease and hospitalization in a. He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. are no data yet for Omicron. Last updated by Judith Stewart, BPharm on Feb 15, 2021. hb``g``oc`c` @1v=k}u F'SUNZ 0000054208 00000 n 54 0 obj Vaccine AstraZeneca in children and adolescents younger than 18 years of age. Authors Maria Deloria Knoll 1 , Chizoba Wonodi 2 Affiliations 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231 USA. 0000004648 00000 n xVN@}W#E{I HTJB+!`)m;:KQyX99se The AstraZeneca vaccine does contain polysorbate. Wait until any effects of the vaccine have worn off before you drive or use machines. If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. 0000002484 00000 n Each vial contains 8 doses of 0.5 ml. Signs of an allergic reaction may include itchy skin rash, shortness of breath and swelling of the face or tongue. Moderna COVID-19 vaccine. , ,p Some affected patients had a previous diagnosis of CLS. Download PDF. << /Type /XRef /Filter /FlateDecode /Length 115 /W [ 1 3 1 ] /Index [ 53 36 ] The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 548 0 obj <> endobj This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The vaccine was administered as two doses of 5 x10 10 viral particles four weeks apart. Neither Pfizer nor Moderna . 0000021326 00000 n The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. No data are currently available in individuals with a weakened immune system or who are taking chronic treatment that suppresses or prevents immune responses. The AstraZeneca vaccine is based on time-tested technology that employs a harmless cold virus (called adenovirus) that has been genetically modified to stimulate an immune response against the coronavirus. hbbd``b` $HpXAv DL) Active ingredients Added ingredients Products used in the manufacture of the vaccine Growing the active ingredients Further information The information on this page is based on the best information that we can find from the available literature. 0 In all participants, a T-cell response was induced, peaking by day 14, and maintained two months after injection. Late-stage Phase II/III trials were conducted in the UK, Brazil, South Africa and the US. 0000098877 00000 n Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). You can help by reporting any side effects you may get. 0000005556 00000 n When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. Dosage level (s) 5 1010 vp (nominal). This is due to the fact that this group is less likely to respond adequately to vaccination following a standard primary LYpeP4 &=C&CBzLL3y20gah!A '1>ederj4+e@Zg Rc`TaPa`2R6r G2p T Getty Images. Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. The Anglo-Swedish firm has . The benefits of booster vaccination are recognized following increasing evidence of waning vaccine effectiveness against mild and asymptomatic SARS-CoV-2 infection over time. 0000103790 00000 n 0000006540 00000 n on AstraZeneca COVID-19 vaccine for reports of very rare side effects. (, SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression (, ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (, A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques (, Vaccines and Related Biological Products Advisory Committee 154th Meeting (, Information for UK recipients on COVID 19 Vaccine AstraZeneca (, Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses (, What are the ingredients in the COVID-19 vaccines? 0000013285 00000 n >> If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. In line with the WHO Prioritization Roadmapand and the WHO Values Framework older adults, Once approved, the drugmaker will work with national governments and international health organizations to monitor vaccine recipients for potential side effects from the vaccine that were not seen in clinical trials (this is called surveillance). The manufacturer URL for this document will be provided once that is available. 0000006792 00000 n i; "32tBa;CC'd&@u^?^02/g`8Ea?U "A Simple Breakdown of the Ingredients in the COVID Vaccines." 11 Jan 2021. 0000054470 00000 n request information about a specific topic, United Kingdom Medicines & Healthcare products Regulatory Agency, University of Oxford Vaccine Knowledge Project, United States Centers for Disease Control and Prevention, A weakened adenovirus, which delivers the the COVID-19 spike glycoprotein (this is the active ingredient; also called the 'antigen'), L-histidine hydrochloride monohydrate (amino acid), Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (, A Novel Chimpanzee Adenovirus Vector with Low Human Seroprevalence: Improved Systems for Vector Derivation and Comparative Immunogenicity (, Adenoviral vectors are the new COVID-19 vaccine front-runners. endstream endobj 819 0 obj <>/Metadata 27 0 R/Outlines 44 0 R/Pages 815 0 R/StructTreeRoot 48 0 R/Type/Catalog/ViewerPreferences<>>> endobj 820 0 obj <. 0000006565 00000 n 0000009594 00000 n 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream 0000007231 00000 n The vaccine does not contain any preservative and should be administered by a healthcare professional. The AstraZeneca vaccine uses a harmless, weakened animal virus (called a viral vector) that contains the genetic code for the coronavirus spike protein. The majority of recipients were White (75.5%), 10.1% were Black and 3.5% were Asian; 55.8% were female and 44.2% male. SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. Vaccine Maker Halts Trial Following Unexplained Illness in Volunteer, Details Emerge on Unexplained Illness in AstraZeneca COVID Vaccine Trial, A Study of a Candidate COVID-19 Vaccine (COV001), New Vaxzevria Data Further Support its Use as Third Dose Booster, Vaxzevria Significantly Boosted Antibody Levels Against Omicron, Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern, Vaxzevria Induced Immunity for at Least One Year Following a Single Dose and Strong Immune Responses Following Either a Late Second Dose or a Third Dose, COVID-19 Vaccine AstraZeneca Effective Against Delta (Indian) Variant, AstraZeneca COVID-19 Vaccine Vaxzevria Authorised for Emergency Use in Japan, AZD1222 US Phase III Primary Analysis Confirms Safety and Efficacy, AZD1222 US Phase III trial Met Primary Efficacy Endpoint in Preventing COVID-19 at Interim Analysis, UK and EU Regulatory Agencies Confirm COVID-19 Vaccine AstraZeneca is Safe and Effective, Update on the Safety of COVID-19 Vaccine AstraZeneca, AstraZeneca Advances Mass Global Rollout of COVID-19 Vaccine Through COVAX, AstraZeneca COVID-19 Vaccine Authorised for Emergency Use by the World Health Organization, COVID-19 Vaccine AstraZeneca Confirms 100% Protection Against Severe Disease, Hospitalisation and Death in the Primary Analysis of Phase III Trials, COVID-19 Vaccine AstraZeneca Authorised for Use in the EU, COVID-19 Vaccine AstraZeneca Recommended for Use in the EU, Serum Institute of India Obtains Emergency Use Authorisation in India for AstraZenecas COVID-19 Vaccine, AstraZenecas COVID-19 Vaccine Authorised for Emergency Supply in the UK, AZD1222 Oxford Phase III Trials Interim Analysis Results Published in The Lancet, AZD1222 Vaccine Met Primary Efficacy Endpoint in Preventing COVID-19, FDA Authorises Restart of the COVID-19 AZD1222 Vaccine US Phase III Trial, COVID-19 Vaccine AZD1222 Clinical Trial Resumed in Japan, Follows Restart of Trials in the UK, Brazil, South Africa and India, COVID-19 Vaccine AZD1222 Clinical Trials Resumed in the UK, Statement on AstraZeneca Oxford SARS-CoV-2 Vaccine, AZD1222, COVID-19 Vaccine Trials Temporary Pause, AstraZenecas Scientific and Social Commitment for COVID-19 Vaccine AZD1222, Development of COVID-19 Vaccine AZD1222 Expands into US Phase III Clinical Trial Across All Adult Age Groups, AstraZeneca Australia & New Zealand Response to the COVID-19 Pandemic, AstraZeneca Concludes Agreement with the European Commission for the Supply of up to 400 Million Doses of AZD1222 COVID-19 Vaccine, COVID-19 Vaccine AZD1222 Showed Robust Immune Responses in All Participants in Phase I/II Trial, Cobra Signs Supply Agreement with AstraZeneca for Manufacture of COVID-19 Vaccine Candidate, AstraZeneca to Supply Europe With Up To 400 Million Doses of Oxford Universitys COVID-19 Vaccine At No Profit, AstraZeneca Takes Next Steps Towards Broad and Equitable Access to Oxford Universitys COVID-19 Vaccine, AstraZeneca Advances Response to Global COVID-19 Challenge as it Receives First Commitments for Oxfords Potential New Vaccine, Investigational ChAdOx1 nCoV-19 Vaccine Protects Monkeys Against COVID-19 Pneumonia, AstraZeneca and Oxford University Announce Landmark Agreement for COVID-19 Vaccine. 0000009283 00000 n It is a proven, safe and relatively old approach. Brand name: AZD1222 If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. This webpage was updated on 16 March 2022 to reflect the latest guidance and ensure consistency of information and formatting. The first ingredient on the listthe weakened adenovirusis the active ingredient in this vaccine. 0000009792 00000 n 2.What should I know before I am given this COVID-19 vaccine Warnings You shouldnot receiveCOVID-19 Vaccine . COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. . . The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. The Janssen COVID-19 Vaccine includes the following ingredients: recombinant, replication-incompetent adenovirus type 26 expressing the SARS -CoV-2 spike protein, citric acid To get around the problem, scientists used virus from a chimpanzee to ensure people would not have any natural immunity to it. 0000097788 00000 n If you forget to go back at the scheduled time, ask your doctor, pharmacist or nurse for advice. Other reactions reported in this group include muscle aches (60%), malaise (61%), chills (56%), and feeling feverish (51%). Organization: Public Health Agency of Canada. Pack sizes (not all pack sizes may be marketed): MedImmune UK Ltd Netherlands. Andrew Pollard has been leading the Oxford vaccine clinical trials in the UK, Brazil, and South Africa. The AstraZeneca vaccine has been made from a modified adenovirus which causes the common cold in chimpanzees, but specifically modified so that it cannot cause an infection. If you have any further questions, ask your doctor, pharmacist or nurse. b AV Q4 8=0 ) If your fever is high and lasts longer than two or three days, or you have other persistent symptoms, this might not be due to side effects of the vaccine and you should follow appropriate advice according to your symptoms. AZD1222 FDA Approval Status. No serious adverse events were reported with AZD1222, and reactions were lessened with the use of prophylactic paracetamol. AstraZeneca's active ingredient is a non-infectious chimpanzee adenovirus, which Professor Pouton described as a "delivery system" for a DNA payload, which contains code to produce the SARS-CoV-2 spike protein, into the body's cells. Vaccine Excipient Summary Excipients Included in U.S. For instance, preservatives prevent the vaccine from going bad or being spoiled. COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). M Ms CZHto ) k [ 4.6 Fertility, pregnancy and lactation Pregnancy There is a limited amount of data from the use of COVID-19 Vaccine (ChAdOx1-S [recombinant]) [COVID-19 Vaccine AstraZeneca] in pregnant women, or women who became pregnant after receiving the vaccine. The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. Neutralising activity against SARS-CoV-2 (as assessed by the MNA80 assay) was seen in 91% of participants one month after vaccination and in 100% of participants who received a second dose. One dose (0.5 ml) contains: This medicinal product has been given authorisation for temporary supply by the UK Department of Health and Social Care and the Medicines & Healthcare products Regulatory Agency. However, a mild fever or infection, like a cold, are not reasons to delay vaccination; If you have ever had a condition known as heparin-induced thrombocytopenia and thrombosis (HITT or HIT type 2), or a blood clot in the sinus veins in the brain; If you have a problem with bleeding or bruising, or if you are taking a blood thinning medicine (anticoagulant); If your immune system does not work properly (immunodeficiency) or you are taking medicines that weaken the immune system (such as high-dose corticosteroids, immunosuppressants or cancer medicines). /Info 87 0 R COVID-19 Vaccine (ChAdOx1 S [recombinant]). 3.What if I am taking, have recently taken or might take other medicinesor 0 0000015637 00000 n If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before you receive this vaccine. 2. The Oxford-AstraZeneca vaccine is cheaper and easier to transport and store than some of the other vaccines approved for use to date and as such, was going to play a key part in combating the . 5. Oxford-AstraZeneca COVID-19 vaccine efficacy. 0000100043 00000 n Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. Nijmegen, 6545CG xref Epub 2020 Dec 8. Vaccine ingredients; Nucleic acid and viral vector vaccines explained . This includes any possible side effects not listed in this leaflet. Like any vaccine, the COVID-19 vaccines do come with potential side effects. The vaccine is safe and effective for all individuals aged 18 and above. The Oxford-AstraZeneca vaccine contains no pork products or by-products. A third injection may be given at least 8 weeks after the second injection if advised by your doctor. 0000004762 00000 n %PDF-1.7 hbbd```b``5d4d""A$a0DEE4$U0 Preliminary findings highlight the urgent need for a coordinated approach for surveillance and evaluation of variants and their potential impact on vaccine effectiveness. Get urgent medical attention if you get symptoms of a severe allergic reaction. Keep vials in outer carton to protect from light. Some of the information might be out of date or no longer relevant. None of the ingredients in this vaccine can cause COVID-19. Safety data sheet. For countries that have not yet achieved high vaccine coverage rates in the high-priority groups and that are experiencing high incidence of COVID-19 cases combined with vaccine supply constraints, longer intervals i.e. 0000107040 00000 n Ingredients in the Pfizer-BioNTech Comirnaty COVID-19 vaccine. This includes any possible side effects not listed in this leaflet. It is your choice to receive the COVISHIELD . This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. We use some essential cookies to make this website work. 0000014217 00000 n This will help to protect you against COVID-19 in the future. Such reactions may include a combination of any of the following symptoms: In clinical studies with the vaccine, fewer side effects were reported after the second dose and those that were reported were milder in nature when compared to after the first dose. Oops! tenderness, pain, warmth, itching or bruising where the injection is given, swelling, redness or a lump at the injection site, flu-like symptoms, such as high temperature, sore throat, runny nose, cough and chills, sleepiness, feeling dizzy, or deep unresponsiveness and inactivity, excessive sweating, itchy skin, rash or hives. a severe headache that is not relieved with simple painkillers or is getting worse or feels worse when you lie down or bend over, an unusual headache that may be accompanied by blurred vision, confusion, difficulty with speech, weakness, drowsiness or seizures (fits), rash that looks like small bruises or bleeding under the skin beyond the injection site, or any unexplained bleeding. 0000107188 00000 n The last nine ingredients on the list are called 'excipients.' vaccination series and are at higher risk of severe COVID-19 disease. 0000003223 00000 n It causes the body to produce its own protection (antibodies) against the virus. %PDF-1.3 % This medicine contains a very small amount of alcohol (2 mg of alcohol (ethanol) per dose of 0.5 ml). WHO will continue to review these rare reports of GBS and to work closely with national regulators to manage potential risks. 0000006503 00000 n 0000003743 00000 n 0000098057 00000 n After withdrawing the final dose, some liquid may remain in the vial. s/s's?3on1;XX(@?<=f@(tv4;r% ~IX SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. Company: AstraZeneca . 0000018147 00000 n On his way to a meeting to present . It is important to remember the benefits of vaccination to give protection against COVID-19 still outweigh any potential risks. COVID-19 Vaccine AstraZeneca contains genetically modified organisms (GMOs). these events. Function. 0000002960 00000 n These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. 346 0 obj <> endobj This type of vaccine technology has been tested for many other diseases such as influenza (flu) and middle east respiratory . When these blood clots do occur, they may be in unusual or atypical locations (e.g. To help pregnant women make this assessment, they should be provided with 57 0 obj <> endobj xref COVID-19 Vaccine AstraZeneca is given to adults aged 18 years and older. There are limited data on the use of COVID-19 Vaccine AstraZeneca in pregnant or breastfeeding women. Treatment for: Prevention of COVID-19. Published March 31, 2021 Updated Aug. 1, 2021. 0000102152 00000 n 0000003715 00000 n impact. 569 0 obj <>/Filter/FlateDecode/ID[<422DFA914F61AD45909E39C193482A39>]/Index[548 34]/Info 547 0 R/Length 105/Prev 177378/Root 549 0 R/Size 582/Type/XRef/W[1 3 1]>>stream Title: Redirect for COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients Author: CDC/NCIRD Subject: Can they overcome their checkered past? 0000001732 00000 n During use it can be stored from 2C to 25C. 3. 0000016862 00000 n 0000010323 00000 n Vaxzevria is made up of another virus (of the adenovirus family) that has been modified to contain the gene for making a protein from SARS-CoV-2, the virus that causes COVID-19. <>stream In someone age 55 - 59 who is diagnosed with COVID-19, the risks of hospitalization for The second key step in these reactions is caused by EDTA, a calcium-binding agent and stabilizer that is added to the AstraZeneca vaccine. Your immune cells then recognise the spike protein as a threat and begin building an immune response against it. shortness of breath, chest pain, leg swelling, leg pain or persistent abdominal (tummy) pain. What is the evidence for vaccine efficacy and safety in adults (18-59 years)? Read all of this leaflet carefully before the vaccine is given because it contains important information for you. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream Of the participants who received AZD1222 without paracetamol, 328 (67%) reported mild to moderate pain after vaccination, and 403 (83%) reported site tenderness. The solution is colourless to slightly brown, clear to slightly opaque. 0000055862 00000 n 0000019840 00000 n Documents provided by AstraZeneca: Study Protocol [PDF] February 19, 2021 Statistical Analysis Plan [PDF] February 28, 2021 More Information Go to Additional Information: Statistical Analysis Plan (SAP) D8110C00001-CSP-amendment-6_Redacted.pdf CSR Synopsis Publications: CDC.

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